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Various transporter-mediated or receptor-mediated transporting processes at the BBB responsible for endogenous molecules, such as transferrin, insulin, low density lipoprotein (LDL), glucose, glutathione, etc., have been targeted for developing brain targeting agents

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Oral lesions presented each as an asymptomatic pigmented dark-brown macule with an intact mucosal surface and well-defined borders, except case 2

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