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Pharmacological blockade of GluN2B or allosteric modulation of GABAA receptors normalizes anxiety and despair behaviors in ethanol-fed rodents, pinpointing these receptors as therapeutic targets (Zhang et al
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Its levels decrease with age, affecting both health and appearance, and contributing to diseases like cancer, diabetes, and neurological disorders
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Similarly, TRP depletion does not reliably induce depressive symptoms in healthy individuals without a history of MDD [7], and mice genetically depleted of brain 5-HT did not develop depressive-like behavior [8]
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