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While protocol-dependent, a common best practice is an off-cycle period that is at least one-third to one-half the length of the on-cycle

A plasma-based analysis and genomic landscape of patients with high tumor mutational burden (TMB-H), microsatellite stable (MSS) colorectal cancer (CRC)

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10.1016/j.npep.2018.07.003 168

The convenience of oral dosing comes with a generally heavier side effect burden