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Description

This effect was mediated via activation of cAMP response element-binding transcription factor in a cAMP/PKA-dependent manner and induction of oxidative defense genes HO-1 and NQO1 [101]

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While primary endpoints of alcohol use reduction were not universally achieved, consistent neuroimaging evidence and subgroup-specific effects point to meaningful modulation of reward pathways

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CNS Drugs 26 (10), 871882

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Alongside well-established side effects like nausea, fatigue, and constipation, researchers found that nearly four percent of Reddit users also described hot flashes, chills, fever, and menstrual changes like irregular or unusually heavy bleeding

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