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Best published PK (Awosemo et al., 2021, rats): ~38% oral bioavailability, ~6 to 7 hr oral half-life

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Factors That Can Reduce Glutathione Levels Several lifestyle and environmental factors can lower the body's natural glutathione levels

In the small intestine (orange cylinder) OCA binds to FXR receptors and through formation of the -klotho-FGF4-FGF19 complex inhibits CYP7A1 and decreases bile acid synthesis

Decisions about therapy are made individually, taking into account concomitant conditions and medications taken.

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