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Clinical trials consistently demonstrate that gastrointestinal symptoms are most pronounced during the initial weeks of treatment and typically diminish as the body adapts to the medication

Cornea 36 (6), 719724

Cryo-electron microscopy (Cryo-EM) has revealed that integrin v8 can bind to latent TGF- (L-TGF-) and activate TGF-/SMAD signaling without releasing TGF- from its latent complex, providing a novel perspective on pathway activation (Campbell et al

This is in line with an eligible study by Lind and colleagues that showed that caffeine at 50 mg.kg -1 was anxiogenic only for high-anxiety groups previously selected in EPM [26]