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Hvis pasienten opplever bivirkninger ved dosekning til neste trinn, reduseres dosen en periode, men forskes dosekning minst n gang til ved et senere tidspunkt, slik det ble gjort i STEP1-studien (9)

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Other neuroprotective mechanisms potentially involved in the treatment of cognitive disorders as well as cerebrovascular disease and epilepsy suggest that GLP-1RAs can enhance the viability of neurons and restore neurite outgrowth by stimulating neurotrophic factors, thus increasing subventricular zone progenitor cells, decreasing apoptosis and the level of pro-inflammatory factors, and strengthening the bloodbrain barrier 37

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