Collagen remodeling is a multi-week process governed by fibroblast gene expression, procollagen synthesis, and matrix metalloproteinase regulation
Psychiatry 57 , 217220 (1994)
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Furthermore, when comparing the combination therapy to the standard treatment, Donepezil, the reduction in A plaque burden in both the cortex and hippocampus was similar between the groups, while the combination group showed a trend towards lower levels of soluble A
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