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However, their long-term use is restricted due to a range of adverse effects, such as immune suppression, increased infection risk, and metabolic disturbances like hyperglycemia.For instance, in rheumatoid arthritis (RA) patients, long-term corticosteroid use has been associated with increased rates of infections and osteoporosis, as well as delayed wound healing, which severely hampers recovery (Rifaai et al., 2012)