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a peak incidence of spina bifida was noted amongst men conceived between February and March 1945, i.e., the depths of the Dutch famine during World War II (60)

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The findings stimulate further studies in large biobank samples to clarify whether such signatures could prove valuable for detecting pathology or follow-up of treatment effect in clinical trials

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The upper limit for supplemental magnesium is 350 mg daily, with higher doses potentially causing diarrhea