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Intriguingly, in an organotypic 3D tissue culture model, mTORC1 supports the expression of aminotransferases and the suppression of GDH in proliferating cells [96]

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TKPT, murine kidney proximal tubular epithelial cells

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This modification enhances its enzymatic activity, leading to increased aerobic glycolysis and metabolic reprogramming in tumor cells, which in turn promotes tumor progression [85]

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