Moreover, dual GLP-1 and Gcg receptor agonist, dual GLP-1/GIP receptor agonist and GLP-1/GIP/Gcg receptor triagonist have also been successfully applied in the treatment of AD models
In a landmark study published in Nature Aging (2021), researchers administered the peptide to mice starting at 23.5 months of age (equivalent to roughly 70 human years)
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Autoimmunity as a Sequela to Obesity and Systemic Inflammation
This dual approach is particularly relevant for MASH, where hepatic steatosis is directly targeted by glucagon-mediated fat oxidation