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Contraindications include active or recent cancer, uncontrolled diabetes, severe diabetic retinopathy, and pregnancy
The research supporting muscle preservation typically uses 5-10 grams of BCAAs with at least 2.5 grams of leucine
A few commenters noted that HCC codes do not appropriately capture the severity of illness, particularly for pain, and that HCC risk scores are designed for predicting cost and utilization across broad medical conditions not the conditions in the ASM cohort
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Nonetheless, this research provides clinically relevant evidence to support the preferential use of GLP-1 RAs over insulin in eligible patients, particularly those at elevated risk for gastrointestinal complications