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Endocrine 46 , 445454 (2014)

We do not know how much of it is absorbed through the skin, but generally, barring a few chemicals such as hydroquinone, absorption from intact skin is minimal

If a patient is suspected to be experiencing OIH, carefully consider appropriately decreasing the dose of the current opioid analgesic, or opioid rotation (safely switching the patient to a different opioid moiety) (see DOSAGE AND ADMINISTRATION, WARNINGS)

Purchasing, possessing, or administering unlicensed substances carries both legal and significant health risks

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