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Pregnancy and breastfeeding : safety has not been established

Doxorubicin and other anthracyclines in cancers: activity, chemoresistance and its overcoming

(PubMed) Fujii T, Salanti G, Belletti A, et al

PMID: 28121423 | doi:10.1021/acs.biochem.6b01215 Akar S et al

And being at the edge means increased risk of bloating , nausea, and other gastrointestinal side effects that make the experience unpleasant

With the reduction of the oxidative phosphorylation complex substrates (output of citric acid cycle) by glycolysis defect or pyruvate dehydrogenase deficiency may result in disturbances on cellular energy production (Armstrong et al