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Optimizing Electron Transport Chain (ETC) Efficiency As a cofactor for lactate dehydrogenase (LDH) , PQQ accelerates NADH-to-NAD+ conversion, enhancing glycolysis

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It decreases the O 2 affinity of hemoglobin, promoting the release of O 2 in peripheral tissue

[DOI] [PubMed] [Google Scholar] Osteen K

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In particular, further research is needed to assess the response in specific subgroups, such as patients with higher BMI, and to compare clinical features between patients with and without muscle cramps to validate these findings