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Physiol Rev 75(3):519560 Krishnan L et al (2003) Effects of angiogenesis on the material properties of the extracellular matrix: correlation with gene expression

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Since these medications have established safety profiles in approved metabolic indications, researchers feel they could potentially be repurposed for addiction treatment more quickly than entirely new drugs, although safety and tolerability in people with alcohol or substance use disorders still require dedicated testing

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The most pronounced improvements in BC were observed after 3 and 6 months of treatment, whereas after 12 months these beneficial effects tended to diminish