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Cagrilintide is only available through clinical trial participation until FDA approval

248 Notably, ER-phagy becomes activated to degrade high-molecular-weight proinsulin aggregates in ERAD-deficient cells

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Exploratory subgroup analysis revealed that individuals with mild obesity, low insulin resistance, and reduced insulin secretionclassified as mild age-related diabetes (MARD)exhibited a more pronounced glucose-lowering response, with a mean reduction of 0.4 mmol/L (p=0.008)