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Hormonal imbalances : Methylation is crucial for estrogen metabolism and detoxification, impacting conditions such as estrogen dominance and PCOS [6]

Similarly, excessive ER- receptors in the endothelial cells of the uterine microvasculature induce cyclooxygenase (COX) and prostaglandin-E2 (PGE 2 ) [72]

We assume that the risk of ESRD imposed by RA accumulates, and that the young patients have temporally more chance to be exposed to the cumulative risk of ESRD during the course of RA