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As mentioned previously, increased cerebrovascular resistance at rest, whether it be related to aging or disease, is typically a negative change in cerebrovascular function and is a sign of greater flow impedanceultimately leading to reductions in CBF (Thomas et al., 2021)

IV therapy addresses one component of this cycle systemic inflammation and nutritional status by delivering antioxidants, anti-inflammatory nutrients, and hydration directly to the bloodstream at concentrations not achievable through oral supplementation

Figure 1 5 Future directions and conclusion Although studies directly investigating the effects of urolithin A on sleep are lacking, there is mechanistic plausibility supporting this potential relationship, representing a novel direction in polyphenol-derived microbial metabolite research

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