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Minich et al

These patterns are supported by clinical observations in SUSTAIN trials and real-world data, where early low-dose phases show limited weight effects compared to later escalation

The downstream benefits like muscle recovery, body composition, and sleep improvement are less robustly proven in healthy adults

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I would say to you humbly, that nobody knowsmechanistically, there is quite a bit to do so that we can make the next-generation better