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DOI: 10.1016/S0090-3019(01)00348-2 12

These typically improve gradually as drug levels decline, though some patients report a temporary worsening of nausea during the first week after discontinuation before improvement occurs

In addition, the applicant and commenter noted that several prior CMS transmittals (#R10997CP, #R11004CP, and #R11801CP) have stated that C1831 is to only be used in lumbar fusion procedures