The direct, quantified, longitudinal human measurements that would settle it are largely absent from the published cagrilintide monotherapy literature, and there is a credible mechanistic reason the tendency of long-acting gut-hormone agonists toward gastric-emptying tachyphylaxis, plus obesity-associated amylin-receptor down-regulation to suspect the gastric arm may attenuate even as central satiety persists
However, significant weight loss may reveal excess skin that was previously stretched due to obesity
Jama (2019) 321(15):14578
Ozempic is manufactured by Novo Nordisk Pharma Ltd
470 BrenuEWHardcastleSLAtkinsonGMvan DrielMLKreijkamp-KaspersSAshtonKJet al
FDA-approved branded options for the same indications are Wegovy and Ozempic (semaglutide, Novo Nordisk), Mounjaro and Zepbound (tirzepatide, Eli Lilly), and Rybelsus (oral semaglutide tablet, Novo Nordisk)