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Ayala and colleagues took a different approach, administering semaglutide to mice for three weeks and conducting continuous, high-resolution measurements of feeding behavior and energy expenditure throughout and after treatment
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d Data are observed (ie, as-measured) numbers and proportions of participants at week 68 from the in-trial period (the time from randomization to last contact with trial site, irrespective of treatment discontinuation or rescue intervention), and where applicable, estimated odds ratios for semaglutide vs liraglutide for the treatment policy estimand (achievement of 5% weight loss was an exploratory end point and not analyzed statistically)
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