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Glutathione's role in mitochondrial protection means that cellular energy production becomes more efficient as oxidative burden declines

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Loss of ZIP13 function disrupts zinc efflux from the Golgi, leading to cytosolic zinc depletion, impaired Smad translocation and defective collagen biosynthesis

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These are dependent on inflammasome activation following the detection of PAMPs which induces physiological changes in the cell including sloughing, cytokine secretion or coordinated cell death, each of which limit bacterial spread (Lamkanfi and Dixit 2017

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