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Concurrent imaging data indicated that microglia play a predominant role in this process, suggesting that cortical plasticity occurs in the brains of FMS patients with FMS and is primarily mediated by microglial activation ( 7.2 Signaling pathway driven-activation (polarization) of central glial cells Mitogen-activated protein kinases (MAPK) signaling pathway: Activation of central glial cells is primarily characterized by morphological changes, upregulation of classical activation markers, expansion of cell populations, and enhanced pro-inflammatory responses
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