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This effect was suggested to be due to multiple mechanisms, including alteration of the bile acid pool, changes in microbiota composition, improvement of hepatic glucose metabolism, and increased release of incretin hormones (204, 205)

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Furthermore, the three most frequently reported pain qualitiesstabbing pain, sharp pain and shooting painwere all reported approximately twice as frequently for dulaglutide compared with semaglutide, and the mean duration of pain postinjection was approximately twice as long for dulaglutide compared with semaglutide

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This detoxification at the cellular level is crucial for preventing chronic diseases and aging

cardiovascular death (including fatal stroke and fatal MI), non-fatal MI (excluding silent MI), non-fatal stroke or hospitalization for unstable angina pectoris