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Individuals adhering to a vegetarian or vegan diet, those aged 50 and above, or people experiencing malabsorption issues are at a higher risk of developing a deficiency

Studies show that up to 90% of individuals following plant-based diets may experience vitamin B12 deficiency

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Notably, in contrast to 23 (HA08), a structurally very similar epimer (HA09) which differs only with regard to one stereogenic center and exhibiting a 100-fold lower affinity to IRAP did not affect spine morphology, indicating a correlation between the capacity to inhibit IRAP and a positive impact on DSD and spine morphology