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Carcinogens such as NNK and PAHs require metabolic activation to exert their carcinogenic effects

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These oxidative injuries have a direct effect in the mitochondrial electron transfer, resulting in an enhanced electron leak and ROS generation that lead to a vicious circle of mitochondrial dysfunction and oxidative stress

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Intestinal alkaline phosphatase, active in both anchored and secreted forms, promotes the growth of LPS-suppressing bacteria such as Bifidobacterium, and limits the number of LPS-producing E