The originally assumed cosmetic effect also had a sexual component
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
Notably, 100% of participants in both the 8 mg and 12 mg groups achieved at least 5% body weight reduction, with 83% of the 12 mg group achieving reductions of 15% or more
Unresolved issues were as follows: 1) crosstalk between ferroptosis and other cell death pathways (e.g., pyroptosis) in LN, 2) interplay of iron metabolism with epigenetic regulation in ferroptosis-driven autoimmunity, and 3) development of LN-specific ferroptosis inhibitors and sensitive renal biomarkers for clinical translation (225)
Immune Support: Glutathione bolsters immune defenses, especially after surgery when the body is more vulnerable
Emerging bispecific antibodies that target CD20 and inhibitory checkpoints could enhance therapeutic precision by localizing immunosuppressive effects specifically to inflamed kidneys