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Second, PPAR agonists, the drugs that lower FA levels by promoting fat synthesis, are expressed in adipose tissue, the liver, skeletal muscle, and immune cells ( Disordered FA metabolism further promotes inflammation, and elevation of the uric acid levels, primarily through high levels of FAs, activates the initiation of inflammation

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It also resulted in a 13.2% decrease in body weight in an East Asian population with overweight or obesity, with or without T2DM

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The peptide-treated group showed significant symptom reduction compared to controls, demonstrating that the approach works across different allergen types

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