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Non-pharmacological interventions remain the cornerstone of weight management and are recommended by NICE for all patients, regardless of whether medication is used: Structured lifestyle programmes : Multicomponent interventions incorporating dietary advice, physical activity, and behavioural support
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Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults
Additionally, it upregulates anti-apoptotic proteins such as Bcl2 while downregulating pro-apoptotic factors like Caspase3 and Bax
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