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In addition, studies have shown that GLP-1RAs decrease oxidative stress and improve endothelial function contributing to a reduction of inflammation in obesity (29)

Activation of GLP-1R also increases intracellular Ca 2+ through Ca 2+ release from the endoplasmic reticulum (ER) via the inositol 1,4,5 triphosphate receptors activated by PKA and the ryanodine receptors activated by Epac2 (9)

doi: 10.1016/j.brainres.2018.03.015 83 Study Group of Functional Gastrointestinal Disorders (2020)

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It originates from the preproglucagon precursor, which undergoes enzymatic processing within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and GLP-1(7-36) amide or GLP-1(7-37) peptide variants