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The studys use of beta-3 receptor knockout mice confirmed the specificity of the lipolytic mechanism, demonstrating that the peptides effects occur exclusively through this peripheral fat tissue pathway

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Negatively charged targets are mainly represented by phospholipids, such as PS, which are secluded in the inner side of the plasmatic membrane in normal cells, but increasing the content of PS and accordingly increasing the cancer cell's negative charge allows for the specificity of ACPs (176,177,178)

doi: 10.1021/jf0206466 108

Its primary mechanism is the upregulation of telomerase, the enzyme responsible for maintaining and extending telomeres, the protective end-caps on DNA strands

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