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The SURPASS trials evaluated its efficacy for type 2 diabetes

Retatrutide is a triple GLP-1/GIP/glucagon receptor agonist that showed up to 24.2% weight loss in phase 2 trials at 48 weeks, potentially exceeding both CagriSema and tirzepatide

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doi: 10.1186/s12967-023-04371-5 [DOI] [PMC free article] [PubMed] [Google Scholar] 45.Natarelli N, Gahoonia N, Sivamani RK

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When separated into tertiles of AST and ALT, triple therapy promoted significant reductions in ALT and AST compared to baseline and conventional therapy