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If microdosing is about small, steady biological nudges, then full doses, or macrodosing, is about reaching the full therapeutic dose needed to create a more pronounced metabolic effect

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In rodent models, liraglutide stimulates calcitonin release and causes C-cell hyperplasia and tumor formation (51)

These effects are always occurring when you are taking thyroid medication and that isnt necessarily a problem

Tatarkiewicz, K., Sablan, E

As previously mentioned, because DPP-4 inhibitors can increase the risk of hypoglycemia when added to insulin or a sulfonylurea, a dose decrease of sulfonylurea and/or insulin should be considered prior to initiation of a DPP-4 inhibitor