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Acknowledgements The authors express their deepest gratitude to Mei Liu and Sanya Pal (Innomics Inc), Xuan-Mai Petterson and her team (Mayo Clinic Metabolomic Core), Eric Saulnier and his team (Diversigen Inc) for their dedicated support in sample processing and project management, and Renyu Li (Innomics Inc) for his invaluable expert assistance in omics analyses

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