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It will be pretty comprehensive, so dont feel shy about skimming

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Amgens long-acting monthly obesity therapy MariTide (maridebart cafraglutide, formerly AMG 133) demonstrated substantial and sustained weight loss in a Phase II trial, with patients achieving an average of 20% weight loss without a plateau, along with cardiometabolic improvements, over 52 weeks

Orforglipron (small molecule): Represents the future paradigm

Or at minimum, take it with a spoonful of peanut butter or a glass of whole milk