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Pharmacokinetic comparisons indicate that intranasal delivery of exenatide or dulaglutide leads to preferential accumulation in the hippocampus and neocortex within 30 min, with higher regional exposure than intravenous administration, even in amyloid precursor protein/presenilin 1 mice ( APP /PS1) transgenic mice [278]

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More generally, how p53 pathway-dependent regulation of nucleotide metabolism links to the broader control of cell fate by p53 requires more detailed investigation

Interestingly, two thirds of such replacements are in highly and moderately conserved (50% to 99%) amino acids, and relatively few are in fully conserved amino acids (where they might be lethal) or in poorly conserved amino acids, where presumably they simply would not cause G6PD deficiency