doi: 10.3390/molecules15031987
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Shishko et al
Although the knockout of GPX7 does not lead to the direct death of mice, the production of excess reactive oxygen species leads to incorrect oxidative modification of proteins and irreversible changes in function, resulting in various diseases
The bottleneck is cellular NAD+ availability
What to avoid when taking glutathione To get the most from glutathione, it helps to reduce the things that deplete it: Alcohol heavily depletes glutathione and burdens the liver Smoking a major source of oxidative stress Excess processed and fried food increases free-radical load Poor sleep and chronic stress both lower natural production There aren't many strict "don't combine with X" rules for healthy adults, but if you take regular medication, have a medical condition, or are pregnant or breastfeeding, talk to your doctor first (see disclaimer below)