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Next, we found that CXCL10 directly bound to IL18R1 to impair ovarian function through three pathways: inducing ovarian fibrosis through p-JNKp-JUN COL1A1, promoting primordial follicle overactivation through p-AKTp-FOXO3A, and increasing ovarian inflammation through p-P65 IFN

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Cagrilintide N-terminal -Glu-fatty acid parameterization The cagrilintide N-terminal -Glu-Fatty acid (-Glu-FA) coordinates were extracted from the Cagri:AMY 3 R:G s complex, retaining K1 Cagri C and N atoms

Houstis, N., Rosen, E