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[9] [10] However, older adults with severe heart failure or significant renal impairment require careful assessment, as dehydration from gastrointestinal side effects may exacerbate kidney function decline and increase acute kidney injury risk

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The same goes for frequent gym-goers and athletes, since intense training temporarily raises oxidative stress as a normal part of recovery

N-Acetylcysteine used to be recommended because it may protect cells from oxidative stress