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The collagen synthesis that fights wrinkles happens primarily during sleep

J Physiol Paris 91:113122 Keremi B, Lohinai Z, Komora P, Duhaj S, Borsi K, Jobbagy-Ovari G, Kallo K, Szekely AD, Fazekas A, Dobo-Nagy C et al (2009) Antiinflammatory effect of BPC 157 on experimental periodontitis in rats

It raises NAD levels. Increased intracellular NAD was reported in cultured adipocyte systems

doi: 10.1038/nbt0598-444 106 CurrierMAGillespieRASawtellNMMahllerYYStroupGCollinsMHet al

10.1371/journal.pone.0070295 175 XuQ.NiH.ChenQ.SunF.ZhouT.LanY.et al

What neither client knows is that both concerns trace back to the same biological decline