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The acidic environment inhibits the infiltration and antitumor function of natural killer (NK) cells, Dendritic cells (DCs), and CD8 + T cells [73,74,75,76,77]

Indole downregulates the expression of LBP in macrophages by activating HTR2B receptors and blocks the IB-/NF-B inflammatory signaling pathway, thus inhibiting the release of proinflammatory factors

noted that the ablation of Selenoprotein F effectively thwarted the emergence of aberrant crypt foci, which are early indicators of colonic neoplasia

This copper-binding peptide is naturally found in human plasma and has been studied for its role in supporting collagen production and skin regeneration

Data availability The data are available from the corresponding author upon reasonable request

537 (7620), 422426 (2016) C