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Reactive oxygen species cause oxidation that exceeds the capacity of antioxidant defense system, leading to oxidative stress (26)

It has also been observed that inherited MPO defects can lead to impaired fungicidal activity which can lead to candidiasis (Cheng et al., 2008)

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In the penumbra, persistent glucose delivery in the setting of inadequate oxygen can drive lactic acidosis and oxidative stress, complicating simple substrate supplementation strategies (Robbins & Swanson, 2014)