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14 As for its mechanism of action, it is known to act by reducing the expression of pro-inflammatory cytokines through the NF-B pathway and inhibiting the expression of COX-2, 5-lipooxygenase (5-LO) and PGE2 synthesis, resulting in a marked reduction in pain and an improvement in joint function

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Vitamin C, Milk Thistle, L-Cysteine, and Vitamin E are also included as supplementary ingredients

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Hmox-1 can also accelerate erastin-induced ferroptosis by generating ROS

Collectively, -KG insufficiency most likely impairs TET activity to inhibit YBX1 transcription