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In patients with diabetes, GLP1 RA initiation was also associated with a lower risk of requiring additional glucoselowering therapy, but no difference in the risk of nonadherence, compared to metformin initiation
When protein intake is too low, the body is more likely to break down muscle to meet energy needs. Spreading protein throughout the day can help maintain satiety and support muscle recovery
Glucagon-like Peptide-1 (GLP-1, 3031 aa) is a natural gastrointestinal incretin hormone of the glucagon peptide family, secreted from the enteroendocrine L-cells in the distal gut to stimulate insulin secretion in response to postprandial hyperglycemia (Figure 1)
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Beyond orforglipron, Lilly's triple-agonist retatrutide, targeting GLP-1, GIP, and glucagon receptors, is widely viewed as the next efficacy benchmark