If side effects are severe or persistent beyond the first few weeks, your GP or diabetes specialist may suggest: Temporary dose reduction Anti-emetic medication for nausea Review of concomitant diabetes medications to reduce hypoglycaemia risk Alternative GLP-1 receptor agonist formulations if oral semaglutide remains poorly tolerated According to NICE guidelines (NG28) , treatment decisions should be individualised based on efficacy, tolerability, patient preference, and cost-effectiveness
McDonald suspects that GLP-1 medicines, as they regulate hunger and digestion hormones, also trigger other metabolic pathways
Compr Physiol (2014) 4(3):101755
Indians deposit most fat in and around the abdomen
Although usually well accepted, some people may have slight side effects, like nausea or upset stomach, which usually go away as the body becomes used to the drug
According to the company: ColonBroom advises against use if you have mood disorders, liver or kidney disease, or are pregnant or breastfeeding
