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Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments

doi: 10.1111/j.1574-6976.1999.tb00393.x 187 ReaM

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Hypoxia then stabilizes HIF-1 and upregulates REST, which suppresses GCLM/GPX4 expression and enhances ACSL4-dependent lipid peroxidationdirectly amplifying ferroptosiswhile also promoting the release of hypoxic extracellular vesicles (EVs) that propagate tubular ferroptosis in a paracrine manner