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These metabolites accumulate when b12 function becomes inadequate, sometimes before serum b12 drops below normal range

Therefore I also bound $r$ to be within the limits found by Seidl et al

[DOI] [Google Scholar] 99.Stupnisek M., Kokot A., Drmic D., Hrelec Patrlj M., Zenko Sever A., Kolenc D., Radic B., Suran J., Bojic D., Vcev A., et al

10.1158/1535-7163.Mct-21-0962 [DOI] [PMC free article] [PubMed] [Google Scholar] Di Donato M., Bilancio A., D'Amato L., Claudiani P., Oliviero M

The interposed nuclei can be divided into the anterior and posterior portions, which in primates are referred to as the emboliform and globose nuclei, respectively

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